Sildenafil
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[Product name] Sildenafil [ Molecular formula ] C22H30N6O4S [ Molecular weight ] 474.58 [ Mechanism of action ] The mechanism of action of Sildenafil citrate involves the release of nitric oxide (NO) in the corpus cavernosum of the penis. NO binds to the receptors of the enzyme guanylate cyclase which results in increased levels of cyclic guanosine monophosphate (cGMP), leading to smooth muscle relaxation (vasodilation) of the intimal cushions of the helicine arteries, resulting in increased inflow of blood and an erection.Sildenafil is a potent and selective inhibitor of cGMP specific phosphodiesterase type 5 (PDE5) which is responsible for degradation of cGMP in the corpus cavernosum. The molecular structure of sildenafil is similar to that of cGMP and acts as a competitive binding agent of PDE5 in the corpus cavernosum, resulting in more cGMP and better erections. Without sexual stimulation, and therefore lack of activation of the NO/cGMP system, sildenafil should not cause an erection. Other drugs that operate by the same mechanism include tadalafil (Cialis) and vardenafil (Levitra).Sildenafil is metabolised by liver enzymes and excreted by both the liver and kidneys. If taken with a high-fat meal, absorption is reduced; the time taken to reach the maximum plasma concentration increases by around one hour, and the maximum concentration itself is decreased by nearly one-third. [ Uses ] Sexual dysfunction The primary indication of sildenafil is treatment of erectile dysfunction (inability to sustain a satisfactory erection to complete intercourse). It use is now standard treatment for erectile dysfunction in all settings, including diabetes.People on antidepressants may experience sexual dysfunction, either as a result of their illness or as a result of their treatment. A 2003 study showed that sildenafil improved sexual function in men in this situation. Following up to earlier reports from 1999, the same researchers found that sildenafil was able to improve sexual function in female patients on antidepressants as well. |
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| NO.1 | From: Martek Mr.Anthony / Vice-President E-mail: ********** |
| Baff company is the perfect choice for raw material supplier. It frees you from worry about Product's quality, and its price is very reasonable, what' s more， they are free shipping all over the world. | |
| NO.2 | From: GNC Mr.Ryan / Manufacturer's Representative E-mail: ********** |
| Baff is a member of Herbal Material Association, which means it take great responsibility to ensure and enhancing good quality health supplement products. It is a GMP (good manufacturing practice) compliant company. | |
| NO.3 | From: USANA Mr.Alexander / Vice-President E-mail: ********** |
| We find that the product ingredient information is very comprehensive. Desides stating the source of the ingredients, Baff goes to the great length to provide the information and clinical studies of each ingredient used. This is a hallmark of high quality product and services of an excellent herbal raw material online store. | |
